This article was originally published here
StatMed. 2022 Apr 5. doi:10.1002/sim.9400. Online ahead of print.
In diagnostic radiology, the multi-case multi-reader design (MRMC) and the free-response receiver operating characteristics (FROC) method are often used in combination. The cross-sectional data generated by the MRMC-FROC study causes difficulties in the corresponding analysis, and the need to include covariates in the model further complicates subsequent analysis. In this article, we propose a regression approach based on three new measures with good interpretability. The correlation structure of the original test results is directly taken into account in the estimation procedure. The proposed method also allows the inclusion of continuous or discrete covariates. Consistent and asymptotically normal estimators are derived for the new measures. Simulation studies are conducted to evaluate the performance of the proposed approach. The simulation results show that the regression approach works well in a wide range of scenarios. We also apply the proposed regression approach to a diagnostic study of computer-assisted diagnosis in lung cancer.
PMID:35384012 | DOI:10.1002/sim.9400